Buy Online Ephedrine 50mg/ml.EPHEDRINE SULFATE Injection, USP(50 mg/mL)Preservative-FreeAmpulProtect from light.Keep ampuls in tray until time of use.DESCRIPTION Ephedrine Sulfate Injection, USP is a sterile, nonpyrogenic solution containing ephedrine sulfate50 mg/mL in water for injection. It is administered by subcutaneous, intramuscular or intravenous injection as an adrenergic agent. The solution contains no bacteriostat, antimicrobial agent or added buffer. The pH is 5.3 (4.5 to 7.0). The osmolar concentration of the 5% solution is 0.35 mOsmol/mL(calc.).Ephedrine Sulfate, USP is a sympathomimetic amine chemically designatedα-[1-(methylamino) ethyl] benzenemethanol sulfate (2:1) (salt). It has the following structural formula:CLINICAL PHARMACOLOGYTherapeutic doses of ephedrine produce mainly relaxation of smooth muscle and, if norepinephrine stores are intact, cardiac stimulation and increased systolic and usually increased diastolic blood pressure. Its vasopressor effect results largely from increased cardiac output and to a lesser extent from peripheral vasoconstriction. Pressor responses to parenteral ephedrine are slower but more prolonged than those produced by epinephrine. Ephedrine stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and party to direct effect on receptors. Ephedrine may deplete norepinephrine stores in sympathetic nerve endings, so that tachyphylaxis to cardiac and pressor effects of the drug may develop. Central nervous system effects are similar to those of amphetamine drugs but less pronounced. The central effects of ephedrine are overshadowed to a large extent by its peripheral actions.Glycogenolysis in the liver is increased by ephedrine but not as much as by epinephrine; usual doses of ephedrine are unlikely to produce hyperglycemia. Ephedrine increases oxygen consumption and metabolic rate as a probable result of central stimulation.
Buy Online Ephedrine 50mg/ml.LPD Reference: EPH50-SIN-0418/0Date of Last Revision: 02 April2022Country: SingaporeReference document: Canada LPD (28-NOV-2022)Reason for change: Reference change to Canada LPD& Formatting and editorial update throughout the document.EPH50-SIN-0418/0Date of Last Revision: April Ephedrine is rapidly and completely absorbed following parenteral injection. Pressor and cardiac responses to ephedrine persist for one hour following intramuscular or subcutaneous administration of 25 to 50mg.Small amounts of ephedrine are slowly metabolizedin the liver; metabolites have been identified as p-hydroxyephedrine, p-hydroxynorephedrine, norephedrine, and conjugates of these compounds.The drug and its metabolites are excreted in the urine, mostly as unchanged ephedrine. Rate of urinary excretion is dependent on urinary pH. Percentage excretion of the drug and its metabolites is increased by acidification of the urine. Elimination half-life of the drug has been reported to be about three hours when the urine is acidified to pH 5 and about six hours when urinary pH is 6.3.